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suatu hari saya pernah di Universitas Airlangga. Saya merasa bangga menjadi bagian dari Universitas Airlangga.

Karena itu Saya dulu pernah tes untuk masuk jadi kecil di Universitas Airlangga dulu saya pernah mengikuti tes di Universitas Airlangga. Karena didorong oleh keinginan keluarga saya ingin masuk di kampus yang terbesar di Surabaya dengan kemauan keras dengan tujuan yang sangat saya impikan untuk menjadi mahasiswa di Universal nggak Saya selalu belajar siang dan malam untuk mendapatkan salah satu bangku di perkuliahan di Universitas Airlangga. Pertama sih Saya belajar di rumah dari pagi siang sore malam untuk mendapatkan impian saya yaitu tempat universitasAirlangga yang dimana. Dewasa ini universitas Airlangga menjadi salah satu rujukan mahasiswa-mahasiswi seluruh Indonesia untuk melakukan ataupun meneruskan bangku perkuliahan nya di Universitas Airlangga ini. Otomatis bagai ksatria airlangga saya mengetik bangga dan saya senang juga menjadi salah satu kampus ataupun kampus 10 terbaik seluruh Indonesia. Besar sangat harapan saya untuk menjadi Universitas Airlangga salah satu kampus impian dan kampus yang terbaik diseluruh antero dunia. Oleh karena itu saya berharap ada adik ataupun teman-teman yang ingin mendapatkan  Airlangga menjadi tempat ukurannya saya harapkan ada di tetap belajar dan bisa meluruskan cita-cita dan niat Dari Hati untuk melakukan perkuliahan universitas Airlangga. Karena banyak sekali dari beberapa kakak kelas saya tidak bisa lulus ataupun wisuda di universitas Airlangga. Jadi saran dari saya untuk adik-adik ingin menuliskan cita-citanya atau impiannya kampus tercinta ini. Jadi punya banyak belajar dan selalu menempelkan gambar patung Airlangga ini di kamar toilet dikasih ataupun tempat-tempat yang bisa melihat impian tersebut untuk kuliah di Universitas Airlangga. Besar sangat impianku saya untuk melakukan perkuliahan di sekolah kedinasan namun kaki sapi cara lain saya takdir oleh Allah kesempatan melanjutkan perkuliahan di Universitas Airlangga. Yah nih ada salah satu cerita saya yang menarik di Universitas Airlangga, yaitu ketemu dengan teman yang sangat aneh ataupun disebut dengan udik anaknya itu merupakan siswa lulusan terbaik dari SMA sooko 2 Mojokerto nama nama inisialnya adalah L. Rumahnya dekat dengan rumah saya yaitu di rungkut Surabaya Jawa Timur Indonesia. Mungkin itu hanya sekilas cerita pengalaman saya menjadi mahasiswa di Universitas Airlangga Mungkin banyak kisah-kisah saya tuliskan ataupun saya bagikan dengan adik-adik sekalian yang baca blog saya ini Nuhun terima kasih wassalamualaikum warahmatullahi wabarakatuh

Study on crystallinity and compactibility of binary mixture of analgesic substances with Microcrystalline cellulose  

Department of Pharmaceutics, Airlangga University, Surabaya, Indonesia 

Abstract
Objectives: The aim of this study was to investigate crystallinity and compatibility transformation of two binary mixtures of analgesic substance with excipient due to mixing and compression. Methods: Analgesic substances used in this study were mefenamic acid (MA) and acetaminophen (AC). Each substance was mixed with microcrystalline selolusa as excipient with drug-excipient ratio of 70:30, 80:20 and 90:10 %w/w then compressed with pressure of 29.4 kN. Characterization was done by Powder X-Ray Diffraction (PXRD), thermal analysis (DTA), FTIR spectrometer and a Scanning Electron Microscope (SEM). Mechanical properties was also evaluated by calculating its tensile strength Results: Evaluation of crystallites size of MA and MA-MCC mixture showed that the value of MA crystallite size is relatively fixed in all the peaks observed. Crystallite size of the AC and AC-MCC mixture also showed similar results with MA. From the elastic modulus curve, it was recognized that the tensile strength of MA is greater than AC, it indicates that the MA is more plastic than AC. Conclution: X-ray powder diffraction of binary mixture indicated that intensity of both MA and AC decreased with increasing amount of MCC. The average crystallite size were 15-19 Å (MA) and 21-30 Å (AC). It was known that MA has compactibility better than AC.

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Study on crystallinity and compactibility of binary mixture of analgesic substances with Microcrystalline cellulose  

Department of Pharmaceutics, Airlangga University, Surabaya, Indonesia 

Abstract
Objectives: The aim of this study was to investigate crystallinity and compatibility transformation of two binary mixtures of analgesic substance with excipient due to mixing and compression. Methods: Analgesic substances used in this study were mefenamic acid (MA) and acetaminophen (AC). Each substance was mixed with microcrystalline selolusa as excipient with drug-excipient ratio of 70:30, 80:20 and 90:10 %w/w then compressed with pressure of 29.4 kN. Characterization was done by Powder X-Ray Diffraction (PXRD), thermal analysis (DTA), FTIR spectrometer and a Scanning Electron Microscope (SEM). Mechanical properties was also evaluated by calculating its tensile strength Results: Evaluation of crystallites size of MA and MA-MCC mixture showed that the value of MA crystallite size is relatively fixed in all the peaks observed. Crystallite size of the AC and AC-MCC mixture also showed similar results with MA. From the elastic modulus curve, it was recognized that the tensile strength of MA is greater than AC, it indicates that the MA is more plastic than AC. Conclution: X-ray powder diffraction of binary mixture indicated that intensity of both MA and AC decreased with increasing amount of MCC. The average crystallite size were 15-19 Å (MA) and 21-30 Å (AC). It was known that MA has compactibility better than AC.

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Prevalence and severity of periodontitis in indonesian patients with rheumatoid arthritis  

a  Department of Oral Medicine, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia
b  Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands
c  Rheumatology Department, Department of Internal Medicine, Dr. Sardjito Hospital, Yogyakarta, Indonesia 

Abstract
Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA. Methods: A full-mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age-, sex-, and smoking-matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses. Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti-inflammatory drugs, whereas none of the controls used such drugs. Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

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Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission  

a  Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
b  Department of Anatomical Pathology, Faculty of Medicine, Dr. Sardjito Hospital, Gadjah Mada University, Yogyakarta, Indonesia
c  Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan 

Abstract
Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. However, the prevalence of hepatitis viral infection and its genotype distribution among hemodialysis patients in Indonesia are unclear. In order to investigate these issues and the possibility of nosocomial transmission, 161 hemodialysis patients and 35 staff members at one of the hemodialysis unit in Yogyakarta, Indonesia, were tested for serological and virological markers of both viruses. HBV surface antigen (HBsAg) was detected in 18 patients (11.2%) and in two staff members (5.7%). Anti-HCV was detected in 130 patients (80.7%) but not in any staff members. Occult HBV and HCV infection were detected in 21 (14.7%) and 4 (12.9%) patients, respectively. The overall prevalence rates of HBV and HCV infection among patients were 24.2% and 83.2%, respectively. HCV infection was independently associated with hemodialysis duration and the number of blood transfusions. Phylogenetic analysis revealed that 23 of 39 tested HBV strains (59%) were genotype B, 11 (28.2%) were genotype C, and 5 (12.8%) were genotype A. HCV genotype 1a was dominant (95%) among 100 tested HCV strains. Nosocomial transmission was suspected because the genotype distribution differed from that of the general population in Indonesia, and because the viral genomes of several strains were identical. These findings suggest that HBV and HCV infection is common among hemodialysis patients in Yogyakarta, and probably occurs through nosocomial infection. Implementation of strict infection-control programs is necessary in hemodialysis units in Indonesia.




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